Measuring proliferation in breast cancer: practicalities and applications.

Mark J Beresford, George D Wilson, Andreas Makris

Journal: Breast cancer research : BCR 2007;8(6):216

PMID: 17164010

Free Full Text on BioMed Central View on PubMed

Abstract

Various methods are available for the measurement of proliferation rates in tumours, including mitotic counts, estimation of the fraction of cells in S-phase of the cell cycle and immunohistochemistry of proliferation-associated antigens. The evidence, advantages and disadvantages for each of these methods along with other novel approaches is reviewed in relation to breast cancer. The potential clinical applications of proliferative indices are discussed, including their use as prognostic indicators and predictors of response to systemic therapy.

Address: Mount Vernon Cancer Centre, Northwood, Middlesex, UK. [email protected]

DOI: 10.1186/bcr1618

Link outs

Free resources

Full Text Sources:

Medical:

https://medlineplus.gov/breastcancer.html

Other Literature Sources:

https://www.lens.org/lens/search/patent/list?q=ref...

MeSH Terms: Antigens, Nuclear, Breast Neoplasms, Cell Proliferation, Cyclin-Dependent Kinases, Cyclins, DNA Topoisomerases, Type II, Deuterium Oxide, Disease Progression, Female, Humans, Ki-67 Antigen, Mitotic Index, Nuclear Proteins, Positron-Emission Tomography, Proliferating Cell Nuclear Antigen, S Phase, Thymidine Kinase, Tissue Array Analysis