Evaluation of PDE4 inhibition for COPD.

Xiangli Cui, Desuo Wang

Journal: International journal of chronic obstructive pulmonary disease 2008;1(4):373-9

PMID: 18044094

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Abstract

Targeting type 4 phosphodiesterase (PDE4) for treatment of COPD has multilevel benefits to patients by reducing inflammation, relieving bronchoconstriction, and improving pulmonary circulation. The isoenzyme-specific narrow spectrum PDE4 inhibitors such as cilomilast and roflumilast may have limited clinical efficacy in managing severe and very severe COPD. Development of dual therapy by combining PDE4 inhibition with Ca2+ channel antagonism may introduce an effective novel armory for physicians to manage patients with severe COPD.

Address: South Carolina College of Pharmacy, University of South Carolina, 715 Sumter St, Columbia, SC 29208, USA. [email protected]

DOI: 10.2147/copd.2006.1.4.373