Rheopheresis in patients with critical limb ischemia--results of an open label prospective pilot trial.

Reinhard Klingel, Bernard Erdtracht, Victor Gauss, Andreas Piazolo, Patrick Mausfeld-Lafdhiya, Curt Diehm

Journal: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 2006;9(6):473-81

PMID: 16354279

Full Text on Ovid Technologies, Inc. View on PubMed

Abstract

Rheopheresis is a specifically designed application of double filtration plasmapheresis, for extracorporeal treatment of microcirculatory disorders. Safety and efficacy of Rheopheresis for wound healing and skin oxygenation were investigated in patients with critical limb ischemia. Twelve patients of Fontaine stage III-IV were treated with a series of 10 Rheopheresis sessions over 17 weeks. Transcutaneous oxygen pressure (tcpO(2)) and ankle-brachial index (ABI) were repeatedly determined to monitor the effects of the Rheopheresis treatment series on microcirculation and skin blood flow. Laboratory parameters of blood rheology were measured in addition to safety parameters and course of the pain syndrome was documented. In four patients (baseline Fontaine stage III) Rheopheresis was associated with an improvement of Fontaine stage, a pronounced increase in tcpO(2) and complete regression of the rest pain. As an adjunct therapeutic option, Rheopheresis may preserve a functional lower extremity, delay amputation or reduce the extent of amputation.

Address: Apheresis Research Institute, Cologne, Germany. [email protected]

DOI: 10.1111/j.1744-9987.2005.00276.x

Link outs

Free resources

Medical:

https://clinicaltrials.gov/search?term=AREA%5BRefe...

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-HLA-B-1

Subscription / membership required

Full Text Sources:

MeSH Terms: Aged, Blood Gas Monitoring, Transcutaneous, Cholesterol, LDL, Female, Fibrinogen, Humans, Immunoglobulin M, Ischemia, Lower Extremity, Male, Middle Aged, Pilot Projects, Plasmapheresis, Prospective Studies, Proteins, Regional Blood Flow, Skin, Treatment Outcome, Wound Healing, alpha-Macroglobulins