Bone tissue lesion in oncological disease (literature review and own research data).

A review of the current literature and our own researches data are presented. Malignant tumors all over the world cause a huge medical social and economic damage, being one of the main causes of people death in all countries. Involving bones in the pathological process occurs in every other patient with cancer. Osteoporosis in patients with malignant tumors is often formed due to disorders of the reproductive and calcium-regulating hormones, we demonstrated the existence of close connection between malignant tumors and bone metabolism disorders. The latter manifests by increase in the synthesis of osteocalcin and osteopontin, the activation of alkaline phosphatase, imbalance of osteo-associated macro elements (calcium, magnesium, phosphorus) and microelements (cobalt, manganese, copper, strontium, chromium, zinc, and others), involving in the pathogenetic constructions of cancer and osteoporosis. We established our data, on the study of osteopontin and other markers of bone metabolism in patients with lung cancer. We found that lung cancer occurs with severe disturbances of bone metabolism, Changes in bone metabolism are aggravated by ongoing chemotherapy and radiation therapy of cancer. These data necessitate the development of anticancer therapy medical technology, which has protective effect toward bone metabolism, and creating of antiosteoporotic treatment, simultaneously directed to the tumor process.