Pentoxifylline and vitamin E combination for superficial radiation-induced fibrosis: a phase II clinical trial.

Peiman Haddad, Bita Kalaghchi, Farnaz Amouzegar-Hashemi

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2006;77(3):324-6

PMID: 16236376

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Abstract

We treated 34 radiation-induced superficial fibrotic lesions with pentoxifylline and vitamin E for 3 months. Mean surface area of the lesions decreased from 112 to 65 cm(2) after treatment (P<0.001). A subgroup of 21 fibrotic lesions received the medications for 6 months, in which surface area decreased from 80 to 27 cm(2) (P<0.001). Pentoxifylline-vitamin E combination improved radiation-induced fibrosis.

Address: Radiation Oncology Department, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran. [email protected]

DOI: 10.1016/j.radonc.2005.09.014

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MeSH Terms: Administration, Oral, Adolescent, Adult, Aged, Antioxidants, Child, Female, Humans, Male, Middle Aged, Pentoxifylline, Radiation Pneumonitis, Radiation-Protective Agents, Severity of Illness Index, Treatment Outcome, Vitamin E