Pharmacological advancements in the treatment of chronic anal fissure.

John H Scholefield, Austin G Acheson

Journal: Expert opinion on pharmacotherapy 2006;6(14):2475-81

PMID: 16259578

Abstract

Chronic anal fissure is a tear in the lining of the anal canal that, if not treated appropriately at an early stage, causes considerable anal pain during defaecation. Surgery is no longer considered the first-line treatment of this common condition, as recent advancements in medical treatment has produced promising results in the healing of fissures, thus avoiding the unwanted complications that frequently occur following operative treatment. This review looks at those pharmacological agents used commonly in the treatment of chronic anal fissures and explores alternative therapies that may be of benefit in the future.

Address: Division of Gastrointestinal Surgery, Queen's Medical Centre, Nottingham, NG7 2UH, UK. [email protected]

DOI: 10.1517/14656566.6.14.2475

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MeSH Terms: Administration, Topical, Adrenergic alpha-Antagonists, Adrenergic beta-Agonists, Albuterol, Botulinum Toxins, Calcium Channel Blockers, Carbachol, Central Nervous System Agents, Cholinergic Agonists, Chronic Disease, Complementary Therapies, Diltiazem, Drug Administration Schedule, Fissure in Ano, Humans, Indoramin, Nitrates, Nitroglycerin, Randomized Controlled Trials as Topic