Effect of zinc and vitamin A supplementation on antibody responses to a pneumococcal conjugate vaccine in HIV-positive injection drug users: a randomized trial.

Maria Deloria-Knoll, Mark Steinhoff, Richard D Semba, Kenrad Nelson, David Vlahov, Curtis L Meinert

Journal: Vaccine 2006;24(10):1670-9

PMID: 16256250

Full Text on Elsevier Science View on PubMed

Abstract

HIV-infected individuals have impaired immune responses to vaccines and high rates of pneumococcal disease. The effect of vitamin A and zinc supplementation on the immunogenicity of a 7-valent pneumococcal CRM-197 conjugate vaccine (PC-7) was evaluated in 118 HIV+ injection drug users. Subjects were randomized to oral 400,000 IU vitamin A, 300 mg zinc, vitamin A + zinc, or placebo, then immunized. Geometric mean titer increased 1.3-3.3-fold for all pneumococcal serotypes. PC-7 elicited an immune response in HIV-infected adults but neither vitamin A nor zinc altered the immunogenicity of the evaluated vaccines.

Address: National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. [email protected]

DOI: 10.1016/j.vaccine.2005.09.047

Link outs

Free resources

Medical:

https://medlineplus.gov/vitamina.html

Other Literature Sources:

https://www.lens.org/lens/search/patent/list?q=ref...

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0264...

MeSH Terms: Adult, Antibodies, Bacterial, Dietary Supplements, Female, HIV Seropositivity, Humans, Immunization, Male, Middle Aged, Pneumococcal Vaccines, Substance Abuse, Intravenous, Vaccines, Conjugate, Vitamin A, Zinc