Effects of ibuprofen and indomethacin on urinary antidiuretic hormone excretion in preterm infants treated for patent ductus arteriosus.

Vincenzo Zanardo, Stefania Vedovato, Paola Lago, Daniele Piva, Diego Faggian, Laura Chiozza

Journal: Fetal diagnosis and therapy 2006;20(6):534-9

PMID: 16260891

Full Text on S. Karger AG, Basel, Switzerland View on PubMed

Abstract

OBJECTIVE

To compare the effects of intravenous ibuprofen and indomethacin for treatment of patent ductus arteriosus (PDA) on urinary antidiuretic hormone (ADH) excretion, as a cause of oliguria.

STUDY DESIGN

Forty-four respiratory distress syndrome prematures (

RESULTS

Indomethacin treatment caused a significant decrease in urinary ADH excretion (21.8 +/- 20.8 vs. 13.8 +/- 12.9 pg/ml; p < 0.05), along with a significant reduction in urinary sodium (92.1 +/- 36.1 vs. 64.8 +/- 35.6; p < 0.05), fractional excretion of sodium (68.5 +/- 37.1 vs. 45.6 +/- 37.1; p < 0.05), and urinary osmolality (276.2 +/- 103.9 vs. 226.4 +/- 60.3; p < 0.05). Ibuprofen treatment did not modify urinary ADH excretion and caused a statistically insignificant decrease in urinary sodium and in fractional excretion of sodium.

CONCLUSIONS

Compared with ibuprofen, indomethacin caused a significant reduction in urinary ADH excretion and a significant decrease in urinary sodium and osmolality.

Address: Pediatrics Department, Padua University School of Medicine, Padua, Italy. [email protected]

DOI: 10.1159/000088046

Link outs

Subscription / membership required

Full Text Sources:

https://doi.org/10.1159/000088046

MeSH Terms: Cyclooxygenase Inhibitors, Ductus Arteriosus, Patent, Humans, Ibuprofen, Indomethacin, Infant, Newborn, Infant, Premature, Oliguria, Respiratory Distress Syndrome, Newborn, Vasopressins