Nutrigenomics: SNPs correlated to Food Preferences and Susceptibilities.

M C Medori, K Dhuli, G Bonetti, K Donato, S Cristoni, M R Ceccarini, T Beccari, A Iaconelli, B Aquilanti, G Matera, K L Herbst, S T Connelly, M Bertelli

Journal: La Clinica terapeutica 2023;174(Suppl 2(6)):214-226

PMID: 37994767

Abstract

BACKGROUND

Nutrigenomics explores the intricate interplay between single nucleotide polymorphisms (SNPs), food preferences, and susceptibilities.

METHODS

This study delves into the influence of SNPs on food sensitivities, allergies, tyramine intolerance, and taste preferences. Genetic factors intricately shape physiological reactions to dietary elements, with polymorphisms contributing to diverse sensitivities and immune responses.

RESULTS

Tyramine intolerance, arising from metabolic inefficiencies, unveils genetic markers exerting influence on enzyme function. SNPs transcend genetic diversity by exerting substantial impact on food sensitivities/allergies, with specific variants correlating to heightened susceptibilities. Genes accountable for digesting food components play pivotal roles. Given the rising prevalence of food sensitivities/allergies, understanding genetic foundations becomes paramount. In the realm of taste and food preferences, SNPs sculpt perception and choice, yielding variances in taste perception and preferences for sweetness, bitterness, and umami. This genetic medley extends its reach to encompass wider health implications.

CONCLUSIONS

In this review article, we have focused on how polymorphisms wield significant sway over physiological responses, sensitivities, and dietary inclinations. Unraveling these intricate relationships illuminates the path to personalized nutrition, potentially revolutionizing tailored recommendations and interventions.

Address: MAGI'S LAB, Rovereto (TN), Italy.; MAGI'S LAB, Rovereto (TN), Italy.; Department of Pharmaceutical Sciences, University of Perugia, Italy.; MAGI EUREGIO, Bolzano, Italy.; MAGISNAT, Atlanta Tech Park, Peachtree Corners, GA, USA.; ISB Ion Source & Biotech-nologies srl, Italy, Bresso, Milano, Italy.; Department of Pharmaceutical Sciences, University of Perugia, Italy.; UOSD Medicina Bariatrica, Fondazione Policlinico Agostino Gemelli IRCCS, Rome, Italy.; Total Lipedema Care, Beverly Hills, California, and Tucson, Arizona, USA.; San Francisco Veterans Af-fairs Health Care System, Department of Oral & Maxillofacial Surgery, University of California, San Francisco, CA, USA.; MAGI'S LAB, Rovereto (TN), Italy.; MAGI EUREGIO, Bolzano, Italy.; MAGISNAT, Atlanta Tech Park, Peachtree Corners, GA, USA.
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