Conjugated linoleic acid increased C-reactive protein in human subjects.

Annika Smedman, Samar Basu, Stefan Jovinge, Gunilla Nordin Fredrikson, Bengt Vessby

Journal: The British journal of nutrition 2005;94(5):791-5

PMID: 16277783

Abstract

We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F2alpha, a marker for cyclooxygenase-mediated lipid peroxidation and thus an indicator of cyclooxygenase-mediated inflammation. The aim of the present study was to investigate the effects of CLA on other indicators of inflammation in human subjects, including C-reactive protein, TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1. In a double-blind, placebo-controlled study, fifty-three human subjects were supplemented with a mixture (4.2 g/d) of the isomers cis-9,trans-11 CLA and trans-10,cis-12 CLA or control oil for 3 months. CLA supplementation increased levels of C-reactive protein (P=0.003) compared with the control group. However, no changes in TNF-alpha, TNF-alpha receptors 1 and 2, and vascular cell adhesion molecule-1 were detected.

Address: Unit for Clinical Nutrition Research, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. [email protected]

DOI: 10.1079/bjn20041419

Link outs

Free resources

Full Text Sources:

https://core.ac.uk/reader/190727067?utm_source=lin...

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-CRP-1

Subscription / membership required

Full Text Sources:

MeSH Terms: Adult, Biomarkers, C-Reactive Protein, Dinoprost, Double-Blind Method, Female, Humans, Inflammation, Linoleic Acids, Conjugated, Male, Middle Aged, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Type II, Regression Analysis, Tumor Necrosis Factor-alpha, Vascular Cell Adhesion Molecule-1