Modifying cancer risk factors: the gene-environment interaction.

Ellen Giarelli, Linda A Jacobs

Journal: Seminars in oncology nursing 2006;21(4):271-7

PMID: 16293515

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Abstract

OBJECTIVES

To examine the concept of risk modification in the context of cancer prevention.

DATA SOURCES

Published articles and research studies on genetic and environmental factors.

CONCLUSION

How the environment is defined frames how the gene-environment interaction is studied and understood. The development of a workable model for risk modification flexible enough to be individualized for a patient is an important step in making primary prevention the goal in cancer care.

IMPLICATIONS FOR NURSING PRACTICE

Nurses working in cancer care are well placed to advise patients on risk-management strategies, and to increase public awareness of the interdependence of environment and genomics on cancer risk.

Address: University of Pennsylvania School of Nursing, 420 Guardian Dr, Philadelphia, PA 19104, USA. [email protected]

DOI: 10.1016/j.soncn.2005.06.008

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MeSH Terms: Clinical Nursing Research, Environmental Exposure, Female, Genetic Predisposition to Disease, Genetic Testing, Health Education, Humans, Life Style, Male, Mass Screening, Neoplasms, Oncology Nursing, Primary Prevention, Risk Assessment, Sensitivity and Specificity