Angiotensin II-induced oxidative burst is fluvastatin sensitive in neutrophils of patients with hypercholesterolemia.

Ildiko Seres, Gabriella Fóris, Dénes Páll, Béla Kosztáczky, Gyorgy Paragh, Zsuzsa Varga, Gyorgy Paragh

Journal: Metabolism: clinical and experimental 2005;54(9):1147-54

PMID: 16125525

Full Text on Elsevier Science View on PubMed

Abstract

The aim of this study was to investigate the effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor fluvastatin (Flu) on angiotensin II (AII)-stimulated neutrophils of patients with hypercholesterolemia. Results suggest that a 6-week-long Flu administration completely counteracted the AII-induced increase in superoxide anion and leukotriene C4 production of the neutrophils of patients with hypercholesterolemia. However, the failure of signal processing through pertussis toxin-sensitive G protein, the increase in [Ca2+]i in membrane-bound protein kinase C activity, and the increase in neutrophil-bound cholesterol content were only partially restored by Flu. In addition, Flu had no effect on the increased membrane rigidity of the neutrophils of patients with hypercholesterolemia. To sum it up, Flu administration had a beneficial effect on AII-triggered reactive oxygen species generation; it resulted in partial restoration of signaling processes and of membrane composition, but membrane fluidity remained unchanged.

Address: First Department of Medicine, Medical and Health Science Center, University of Debrecen, H-4012 Debrecen, Hungary.

DOI: 10.1016/j.metabol.2005.03.021

Link outs

Free resources

Medical:

https://medlineplus.gov/cholesterolmedicines.html

Miscellaneous:

https://assays.cancer.gov/non-CPTAC-3339

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0026...

MeSH Terms: Aged, Angiotensin II, Calcium, Cells, Cultured, Fatty Acids, Monounsaturated, Fluvastatin, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypercholesterolemia, Indoles, Leukotriene C4, Male, Membrane Fluidity, Middle Aged, Neutrophils, Reactive Oxygen Species, Respiratory Burst, Signal Transduction, Vasoconstrictor Agents