Effects of an Individualized vs. Standardized Vitamin D Supplementation on the 25(OH)D Level in Athletes.

Chiara Tuma, Arne Schick, Nele Pommerening, Hans Braun, Mario Thevis

Journal: Nutrients 2023;15(22):4747

PMID: 38004144

Plain Language Summary

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Vitamin D has hormone-like effects that exert its actions ubiquitously in the human body. This is why it is not only indispensable for general health but also plays a role in athletes’ performance. Vitamin D supplementation plays a central role in covering vitamin D needs. Especially in winter months, when the UV index is too low for endogenous vitamin D synthesis. This study aimed to 1) determine whether an individual loading dose formula for vitamin D supplementation is more effective than standardized supplementation, and 2) assess whether athletes can achieve a target Vitamin D3 - 25(OH)D level of 40 ng/mL. This study was a randomised controlled intervention study conducted during winter months in Germany. Ninety athletes with insufficient vitamin D levels (25(OH)D < 30 ng/mL) were randomly assigned to one of the two groups (standardised or individualised) and received either a universal dose: 2000 IU/day of vitamin D or a loading dose: 4000 IU/day, followed by a maintenance dose of 1000 IU/day. Results showed that: - The individualised group achieved significantly higher 25(OH)D levels (41.1 ± 10.9 ng/mL) compared to the standardised group (32.5 ± 6.4 ng/mL). - the daily maintenance dose for athletes should be higher than 1000 IU to maintain a 25(OH)D concentration of 40 ng/mL throughout the winter months. Authors concluded that their findings indicate that an individualised approach for insufficient vitamin D status correction offers a more reliable and controlled strategy than a standardised approach. Thus, practitioners should consider regular vitamin D monitoring throughout the winter months combined with a personalised vitamin D strategy.

Abstract

Vitamin D is crucial to the health and performance of athletes. Although the exact vitamin D requirements for athletes have not been established, maintaining a 25(OH)D level of at least 40 ng/mL is considered beneficial. This randomized controlled intervention study aimed to determine whether an individual loading dose formula for vitamin D supplementation is more effective than standardized supplementation and suitable enough for athletes to meet a target value of 40 ng/mL. In a 10-week supplementation study conducted during the winter months in Germany, 90 athletes with insufficient vitamin D levels (25(OH)D < 30 ng/mL) were randomly assigned to receive either a universal dose of 2000 IU/day of vitamin D or a loading dose of 4000 IU/day, followed by a maintenance dose of 1000 IU/day. The total 25(OH)D concentration was measured from dried blood spots at three time points: at baseline, at the computed date of 40 ng/mL, and after the 10-week period. Additionally, a vitamin-D-specific questionnaire was issued. On the day when 25(OH)D blood concentrations of 40 ng/mL were calculated to prevail, the individualized group had a significantly higher 25(OH)D level than the standardized group (41.1 ± 10.9 ng/mL vs. 32.5 ± 6.4 ng/mL, < 0.001). This study demonstrated that the examined formula is suitable enough for athletes to achieve a 25(OH)D concentration of 40 ng/mL. This indicates that a personalized approach is more effective than a one-size-fits-all approach in restoring adequate vitamin D levels in athletes.

Address: Institute of Biochemistry/Center of Preventive Doping Research, German Sport University Cologne, 50933 Cologne, Germany.; German Research Centre of Elite Sports (Momentum), German Sport University Cologne, 50933 Cologne, Germany.; European Monitoring Center for Emerging Doping Agents, 50933 Cologne, Germany.
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