Neurotransmission: emerging roles of endocannabinoids.

Anatol C Kreitzer

Journal: Current biology : CB 2005;15(14):R549-51

PMID: 16051162

Abstract

Postsynaptic release of endocannabinoids can inhibit presynaptic neurotransmitter release on short and long timescales. This retrograde inhibition occurs at both excitatory and inhibitory synapses and may provide a mechanism for synaptic gain control, short-term associative plasticity, reduction of synaptic crosstalk, and metaplasticity.

Address: Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94305, USA.

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