Hypothesis: could Meniere's disease be a channelopathy?

P Gates

Journal: Internal medicine journal 2006;35(8):488-9

PMID: 16176473

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Abstract

Meniere's disease is a clinical syndrome of uncertain aetiology but it is a widespread belief that it is related to endolymphatic hydrops. Clinically, it is a paroxysmal disorder with vertigo and subsequent deafness. It is responsive to acetazolamide and sensitive to the sodium content in the diet, many of the features of the channelopathies. The present paper explores the possibility that it may be related to a channelopathy.

Address: Neuroscience Department, Geelong Hospital, Barwon Health, Geelong, Victoria, Australia. [email protected]

DOI: 10.1111/j.1445-5994.2005.00891.x

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MeSH Terms: Acetazolamide, Adult, Aged, Disease Progression, Endolymphatic Hydrops, Female, Genetic Predisposition to Disease, Hair Cells, Auditory, Inner, Hearing Loss, Sensorineural, Humans, Male, Meniere Disease, Middle Aged, Prognosis, Recurrence, Risk Assessment, Severity of Illness Index, Vertigo