Alicyclic beta-amino acids in Medicinal Chemistry.

A Kuhl, M G Hahn, M Dumić, J Mittendorf

Journal: Amino acids 2006;29(2):89-100

PMID: 15986181

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Abstract

The structural element of alicyclic beta-amino acids shows some remarkable biological effects: For some 5- and 6-membered beta-amino acids a unique anti fungal activity has been observed, 7-membered beta-amino acid derivatives have been investigated for neurological disorders. The application of 5-, 6- and 7-membered alicyclic beta-amino acids in Medicinal Chemistry will be reported. [structure: see text]

Address: Medicinal Chemistry, Business Group Pharma, Bayer Health Care AG, Wuppertal, Germany.

DOI: 10.1007/s00726-005-0212-y

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MeSH Terms: Amino Acids, Cyclic, Antifungal Agents, Central Nervous System Agents, Cycloleucine, Dopamine Plasma Membrane Transport Proteins, Stereoisomerism, Structure-Activity Relationship