How cholesterol-dependent cytolysins bite holes into membranes.

Thomas Walz

Journal: Molecular cell 2005;18(4):393-4

PMID: 15893721

Free Full Text on Elsevier Science View on PubMed

Abstract

In a show piece for electron microscopy (EM), Tilley at al. used single-particle cryo-EM to visualize the structural rearrangements in the bacterial toxin pneumolysin that occur when it assembles into a membrane-associated prepore and when the prepore subsequently transitions into a fully membrane-inserted pore.

Address: Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA. [email protected]

DOI: 10.1016/j.molcel.2005.04.018

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MeSH Terms: Bacterial Proteins, Cell Membrane, Cholesterol, Cryoelectron Microscopy, Cytotoxins, Protein Structure, Tertiary, Streptolysins