Effect of pravastatin on cerebral infarcts and white matter lesions.

V H ten Dam, D M J van den Heuvel, M A van Buchem, R G J Westendorp, E L E M Bollen, I Ford, A J M de Craen, G J Blauw

Journal: Neurology 2006;64(10):1807-9

PMID: 15911821

Abstract

The authors examined the effect of pravastatin 40 mg daily on the progression of ischemic brain lesions using repeated brain MRI. After a mean treatment period of 33 months, there was an increase in total ischemic lesion load of 1.1 cm3 (p < 0.001) in the 270 placebo-treated subjects and 1.1 cm3 (p < 0.001) in the 265 pravastatin-treated subjects. There was no difference between the two treatment groups (p = 0.73).

Address: Department of Internal Medicine, Leiden University Medical Center, The Netherlands. [email protected]

DOI: 10.1212/01.WNL.0000161844.00797.73

Link outs

Subscription / membership required

Full Text Sources:

MeSH Terms: Aged, Aged, 80 and over, Brain Ischemia, Cerebral Infarction, Cholesterol, LDL, Disease Progression, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Intracranial Arteriosclerosis, Magnetic Resonance Imaging, Male, Nerve Fibers, Myelinated, Pravastatin, Prospective Studies, Telencephalon, Treatment Failure