Gabapentin-induced myopathy in 2 patients on short daily hemodialysis.

Jennifer Lipson, Susan Lavoie, Deborah Zimmerman

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 2005;45(6):e100-4

PMID: 15957120

Full Text on Elsevier Science View on PubMed

Abstract

Gabapentin is an antiepileptic medication that also has been used for restless legs syndrome. The mechanism of action is unknown. The most commonly reported adverse effects of this medication include somnolence, dizziness, ataxia, fatigue, nystagmus, and tremor. Myalgia has been reported in 2% of gabapentin users compared with 1.9% of patients in placebo-controlled add-on trials. Two patients on short daily hemodialysis therapy developed neuromuscular symptoms and an elevation in creatine kinase levels after starting gabapentin therapy. To our knowledge, this is the first case report of an increase in creatine kinase level after the administration of gabapentin.

Address: Ottawa Hospital, Department of Medicine, Kidney Research Centre, University of Ottawa, Ontario, Canada.

DOI: 10.1053/j.ajkd.2005.02.024

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MeSH Terms: Adult, Amines, Anticonvulsants, Atorvastatin, Calcium Channels, Comorbidity, Cyclohexanecarboxylic Acids, Gabapentin, Glomerulonephritis, Glomerulonephritis, Membranoproliferative, Heptanoic Acids, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Kidney Failure, Chronic, Kidney Transplantation, Male, Middle Aged, Neuromuscular Diseases, Peritoneal Dialysis, Physical Exertion, Postoperative Complications, Pyrroles, Recurrence, Renal Dialysis, Restless Legs Syndrome, gamma-Aminobutyric Acid