RPE lipofuscin and its role in retinal pathobiology.

Mike Boulton, Janet R Sparrow

Journal: Experimental eye research 2005;80(5):595-606

PMID: 15862166

Full Text on Elsevier Science View on PubMed

Abstract

Emerging evidence indicates that the autofluorescent pigments that accumulate as lipofuscin in retinal pigment epithelial (RPE) cells may reach levels that contribute to a decline in cell function. Since recent findings with respect to the origin, composition and adverse effects of RPE lipofuscin have informed our view of this material, the goal of this article is to review our current understanding of these issues.

Address: Department of Ophthalmology, Columbia University, 630 W 168th Street, New York, NY 10032, USA. [email protected]

DOI: 10.1016/j.exer.2005.01.007

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MeSH Terms: Aging, Humans, Light, Lipofuscin, Melanosomes, Microscopy, Fluorescence, Oxidation-Reduction, Photoreceptor Cells, Pigment Epithelium of Eye, Pyridinium Compounds, Retinal Diseases, Retinoids, Vitamin A