Centromeric chromatin makes its mark.

Elaine Dunleavy, Alison Pidoux, Robin Allshire

Journal: Trends in biochemical sciences 2005;30(4):172-5

PMID: 15817392

Full Text on Elsevier Science View on PubMed

Abstract

Post-translational modifications of core histones, particularly in the N terminus, seem to define different chromatin states in the genome. For instance, actively transcribed regions of euchromatin have a completely different set of 'marks' compared with silent heterochromatin. Recent analyses surprisingly demonstrate that, in addition to containing the histone H3 variant CENP-A, the centromeric chromatin that underlies the kinetochore bears a distinct combination of histone H3 modifications.

Address: Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK.

DOI: 10.1016/j.tibs.2005.02.007

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MeSH Terms: Amino Acid Sequence, Centromere, Chromatin, Histones, Molecular Sequence Data, Protein Processing, Post-Translational