Constituents of the leaves and twigs of Calyptranthes pallens collected from an experimental plot in Southern Florida.

Tatiana Lobo-Echeverri, J Fausto Rivero-Cruz, Bao-Ning Su, Hee-Byung Chai, Geoffrey A Cordell, John M Pezzuto, Steven M Swanson, D Doel Soejarto, A Douglas Kinghorn

Journal: Journal of natural products 2005;68(4):577-80

PMID: 15844953

Full Text on American Chemical Society View on PubMed

Abstract

Fractionation of the chloroform-soluble extract of the leaves and twigs of Calyptranthes pallens, collected from an experimental plot in a hardwood forest of southern Florida, using a hormone-dependent human prostate carcinoma (LNCaP) tumor cell line, led to the isolation of a phloroglucinol derivative with a novel carbon skeleton, pallenic acid (1), and a new triterpenoid, 3beta-hydroxy-18alpha,19alpha-urs-20-en-28-oic acid (2). The known compound methylene-bis-aspidinol (3) was selectively active against the human oral epidermoid carcinoma (KB) cell line. Several known compounds of the ellagic acid, lignan, phloroglucinol, sterol, and triterpene types were also obtained in the present investigation.

Address: Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA.

DOI: 10.1021/np0496688