Iridoids and other constituents from the leaves and stems of Valeriana officinalis var. latifolia.

Jia-Jin Liu, Jun-Jie Hao, Min Tan, Cai-Cen Liao, Dan Liu, Hong-Mei Li, Rong-Tao Li

Journal: Phytochemistry 2024;218():113934

PMID: 38029951

Full Text on Elsevier Science View on PubMed

Abstract

Fifty-nine compounds, including nineteen previously undescribed iridoids (valeriananols A-S) and an undescribed alkaloid (5'-isovaleryl uridine), were isolated from the leaves and stems of Valeriana officinalis var. latifolia. Their structures were elucidated based on Mass spectrometry and NMR spectroscopy. The absolute configuration of valeriananols A-C, E-N, P, Q and S was determined by experimental and calculated electronic circular dichroism. Structurally, valeriananols A and B were two 1,3-seco-iridoids with a 3,6-epoxy moiety, valeriananols K and L were a pair of C-4 epimers, while valeriananol S was a 4'-deoxy iridoid glycoside. In addition, valeriananol P, stenopterin A and patriscabioin C exhibited significant inhibition on nitric oxide production with IC values of 10.31, 3.93 and 8.69 μM, respectively. Furthermore, stenopterin A and patriscabioin C showed anti-proliferation activity on the MCF-7 cell line with IC values of 17.28 and 13.89 μM, respectively.

Address: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, PR China.; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, PR China. Electronic address: [email protected].; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, PR China. Electronic address: [email protected].

DOI: 10.1016/j.phytochem.2023.113934

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MeSH Terms: Molecular Structure, Valerian, Iridoids, Plant Roots, Magnetic Resonance Spectroscopy