Mutational study of the 1p located genes p18ink4c, Patched-2, RIZ1 and KIF1B in oligodendrogliomas.

M Eva Alonso, M Josefa Bello, Dolores Arjona, Pilar Gonzalez-Gomez, Cinthia Amiñoso, Isabel Lopez-Marín, Jose M de Campos, Alberto Isla, Jesús Vaquero, Manuel Gutierrez, Jose L Sarasa, Juan A Rey

Journal: Oncology reports 2005;13(3):539-42

PMID: 15711769

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Abstract

Loss of 1p heterozygosity is one of the most characteristic events in oligodendrogliomas. Several genes located in this region have been previously studied to find the target gene implicated in the development of this tumor without success. Patched-2, RIZ1 and KIF1B are novel oncosuppressor genes located at 1p and involved in different kinds of tumors. We have studied these genes and p18(ink4c) using PCR/SSCP methods to detect sequence variations in a series of 40 oligodendrogliomas in which the allelic status at 1p was analyzed. Polymorphisms or no sequence changes were detected in all four genes analyzed. None of the genes analyzed seem to be the target-gene mapped at 1p involved by mutation in oligodendroglioma development.

Address: Departamento de Cirugía Experimental, Laboratorio de Oncogenética Molecular, Unidad de Investigación, Hospital Universitario La Paz, Po. de la Castellana 261, 28046 Madrid, Spain. [email protected]

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MeSH Terms: Brain Neoplasms, Cell Cycle Proteins, Cell Transformation, Neoplastic, Cyclin-Dependent Kinase Inhibitor p18, DNA Mutational Analysis, DNA-Binding Proteins, Histone-Lysine N-Methyltransferase, Humans, Kinesins, Loss of Heterozygosity, Membrane Proteins, Nerve Tissue Proteins, Nuclear Proteins, Oligodendroglioma, Patched Receptors, Patched-2 Receptor, Polymerase Chain Reaction, Polymorphism, Genetic, Polymorphism, Single-Stranded Conformational, Protein Kinase Inhibitors, Receptors, Cell Surface, Retinoblastoma Protein, Transcription Factors, Tumor Suppressor Proteins