New prodiginines from a ketosynthase swap.

Ronald J Parry

Journal: Chemistry & biology 2005;12(2):145-6

PMID: 15734641

Full Text on Elsevier Science View on PubMed

Abstract

The prodiginine antibiotics exhibit antitumor and immunosuppressive activity. In this issue of Chemistry & Biology, Reynolds and coworkers demonstrate that new prodiginines can be obtained by substituting a FabH ketosynthase for the RedP ketosynthase in the undecylprodiginine biosynthetic gene cluster.

Address: Department of Chemistry, Rice University, Houston, Texas 77005, USA.

DOI: 10.1016/j.chembiol.2005.01.007

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MeSH Terms: Acetyltransferases, Anti-Bacterial Agents, Fatty Acid Synthase, Type II, Multienzyme Complexes, Pigments, Biological, Prodigiosin, Streptomyces coelicolor