Deficiencies of physiologic calcification inhibitors and low-grade inflammation in arterial calcification: lessons for cartilage calcification.

Robert Terkeltaub, Frank Rutsch

Journal: Joint bone spine 2005;72(2):110-8

PMID: 15797489

Full Text on Elsevier Science View on PubMed

Abstract

Apart from clinical parallels, similarities in the pathogenesis of arterial and articular cartilage calcification have come to light in recent years. These include the roles of aging, of chronic low-grade inflammation and of genetic and acquired dysregulation of inorganic pyrophosphate (PP(i)) metabolism. This review focuses on recent developments in understanding the pathogenesis of artery calcification pertinent to interpretation of the mechanistic basis for articular cartilage calcification in aging and osteoarthritis.

Address: Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Münster, Albert-Schweitzer-Strasse 33, D-48149 Münster, Germany. [email protected]

DOI: 10.1016/j.jbspin.2004.05.014

Link outs

Free resources

Medical:

https://medlineplus.gov/vasculardiseases.html

Miscellaneous:

https://assays.cancer.gov/non-CPTAC-3340

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S1297...

MeSH Terms: Arteries, Arteritis, Calcinosis, Calcium-Binding Proteins, Cartilage, Articular, Chondrocalcinosis, Extracellular Matrix Proteins, Humans, Phosphoric Diester Hydrolases, Pyrophosphatases, Vascular Diseases, Matrix Gla Protein