A Shared Perspective on and Models to Assay Intestinal Transepithelial Transport of Food Compounds.

Linda Giblin, Beatriz Miralles, Isidra Recio, Santiaga María Vivanco-Maroto, Lidia Tomás-Cobos, Laura Soriano-Romaní, Marta Santos-Hernández, Lorena Ruiz, Helena Ramos, Alina Kondrashina, Brigitte Anna Graf, Arancha Hevia, Didier Dupont, Wieneke Dijk, Milena Corredig, Shanna Bastiaan-Net, Elena Arranz, Paula Alvito, Bruna Alves, Valérie Petit, Miguel Angelo Faria, Patricia Ruas-Madiedo

Journal: Journal of agricultural and food chemistry 2023;71(49):19265-19276

PMID: 38035628

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Abstract

Assessing nutrient bioavailability is complex, as the process involves multiple digestion steps, several cellular environments, and regulatory-metabolic mechanisms. Several models of different physiological relevance are used to study nutrient absorption, providing significant challenges in data evaluation. However, such models are needed for mechanistic studies as well as to screen for biological functionality of the food structures designed. This collaborative work aims to put into perspective the wide-range of models to assay the permeability of food compounds considering the particular nature of the different molecules, and, where possible, data are provided for comparison.

Address: Dairy Research Institute of Asturias (IPLA-CSIC), Paseo Río Linares, sn. Villaviciosa 33300, Asturias. Spain.; LAQV/REQUIMTE, Laboratório de Bromatologia e Hidrologia, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.; Nestlé Research, Société des Produits Nestlé SA, 1000 Lausanne, Switzerland.; Faculty of Sciences, University of Lisboa, Campo Grande, 1749-016 Lisboa Portugal.; Food and Nutrition Department, National Institute of Health Dr. Ricardo Jorge, 1649-016 Lisbon, Portugal.; CESAM - Centre for Environmental and Marine Studies, University of Aveiro, 3810-193 Aveiro, Portugal.; Department of Nutrition and Food Science, Faculty of Pharmacy, Complutense University of Madrid (UCM), E-28040 Madrid, Spain.; Wageningen Food & Biobased Research, Wageningen University & Research, 6708 WG Wageningen, The Netherlands.; Department of Food Science, Aarhus University, Agro Food Park 48, 8200 Aarhus, Denmark.; INRAE, UR BIA, F-44316, Nantes, France.; INRAE Agrocampus Ouest, STLO, F-35042 Rennes, France.; Teagasc Food Research Centre, Moorepark, Fermoy, P61 C996 County Cork, Ireland.; Department of Health Professions, Faculty of Health and Education, Manchester Metropolitan University, M15 6BH Manchester, U.K.; H&H Group, H&H Research, Global Research and Technology Centre, P61 K202 Cork, County Cork, Ireland.; Wellcome Trust - MRC Institute of Metabolic Science, Metabolic Research laboratories, Addenbrooke's Hospital, Hills Road, CB2 0QQ Cambridge, U.K.; AINIA in Vitro Preclinical Studies Area, Parque Tecnológico de Valencia. c/Benjamín Franklin, 5-11, E46980 Paterna, Spain.; Institute of Food Science Research CIAL (CSIC-UAM), C/Nicolás Cabrera 9, 28049 Madrid, Spain.

DOI: 10.1021/acs.jafc.3c05479

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MeSH Terms: Humans, Biological Transport, Intestines, Food, Intestinal Absorption, Caco-2 Cells