Genotype, phenotype and cancer: role of low penetrance genes and environment in tumour susceptibility.

Ashwin Kotnis, Rajiv Sarin, Rita Mulherkar

Journal: Journal of biosciences 2005;30(1):93-102

PMID: 15824445

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Abstract

Role of heredity and lifestyle in sporadic cancers is well documented. Here we focus on the influence of low penetrance genes and habits, with emphasis on tobacco habit in causing head and neck cancers. Role of such gene-environment interaction can be well studied in individuals with multiple primary cancers. Thus such a biological model may elucidate that cancer causation is not solely due to genetic determinism but also significantly relies on lifestyle of the individual.

Address: Genetic Engineering, ACTREC, Tata Memorial Centre, Kharghar, Navi Mumbai 410 208, India.

DOI: 10.1007/BF02705154

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MeSH Terms: Environment, Epigenesis, Genetic, Genetic Determinism, Genetic Predisposition to Disease, Genotype, Humans, Life Style, Neoplasms, Penetrance, Phenotype, Polymorphism, Single Nucleotide