Antiproliferative effects of daucane esters from Ferula communis and F. arrigonii on human colon cancer cell lines.

F Poli, G Appendino, G Sacchetti, M Ballero, N Maggiano, F O Ranelletti

Journal: Phytotherapy research : PTR 2005;19(2):152-7

PMID: 15852493

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Abstract

Certain jaesekanadiol p-hydroxy- and p-methoxybenzoates - typical of Ferula communis and Ferula arrigonii sardinian plants - show antiproliferative activity on human colon cancer less. The inhibitory doses 50%, calculated after 72 h of treatment, revealed that the antiproliferative capacity of the compounds was in the following descending order: ferutinin > 2alpha-OH-ferutidin > ferutidin > siol anisate > lapiferin > jaeskeanadiol. Evidence is presented that interaction with type II estrogen-binding sites (EBS) underlies this activity.

Address: Department of Evolutionary and Experimental Biology, University of Bologna, Italy.

DOI: 10.1002/ptr.1443

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MeSH Terms: Antineoplastic Agents, Phytogenic, Cell Cycle, Cell Line, Tumor, Cell Proliferation, Colonic Neoplasms, Ferula, Humans, Phytotherapy, Plant Extracts