Ifosfamide encephalopathy: a case report.

Michele Pavarana, Rolando Nortilli, Francesca Valcamonico, Silvia Romito, Tiziano Zanoni, Gianluigi Cetto

Journal: Tumori 2005;91(2):197-200

PMID: 15948552

Abstract

The aim of this short communication is to discuss the mechanism, modality and treatment of ifosfamide encephalopathy. We present the case of a 52-year-old woman treated with this alkylating agent who developed severe neurotoxicity. It was resolved with administration of Methylene blue, abundant intravenous hydration and interruption of ifosfamide.

Address: Department of Clinical and Experimental Medicine, Section of Medical Oncology, University of Verona, Italy. [email protected]

DOI: 10.1177/030089160509100218

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MeSH Terms: Brain Diseases, Electroencephalography, Female, Humans, Ifosfamide, Middle Aged, Sarcoma