Anti-SSA/Ro antibodies and the heart: more than complete congenital heart block? A review of electrocardiographic and myocardial abnormalities and of treatment options.

Nathalie Costedoat-Chalumeau, Zahir Amoura, Elisabeth Villain, Laurence Cohen, Jean-Charles Piette

Journal: Arthritis research & therapy 2005;7(2):69-73

PMID: 15743492

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Abstract

Apart from complete and incomplete congenital heart block (CHB), new cardiac manifestations related to anti-SSA/Ro antibodies have been reported in children born to mothers bearing these antibodies. These manifestations include transient fetal first-degree heart block, prolongation of corrected QT (QTc) interval, sinus bradycardia, late-onset cardiomyopathy, endocardial fibroelastosis and cardiac malformations. Anti-SSA/Ro antibodies are not considered pathogenic to the adult heart, but a prolongation of the QTc interval has recently been reported in adult patients and is still a matter of debate. Treatment of CHB is not well established and needs to be assessed carefully. The risks and benefits of prenatal fluorinated steroids are discussed.

Address: Service de Médecine Interne, Centre Hospitalier Universitaire Pitié-Salpêtrière, Paris, France. [email protected]

DOI: 10.1186/ar1690

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https://medlineplus.gov/heartdiseaseinwomen.html

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-CALR-1

MeSH Terms: Adult, Age of Onset, Antibodies, Antinuclear, Autoimmune Diseases, Betamethasone, Bradycardia, Cardiomyopathies, Child, Child, Preschool, Clinical Trials as Topic, Dexamethasone, Electrocardiography, Endocardial Fibroelastosis, Female, Fetal Heart, Heart Block, Heart Defects, Congenital, Heart Diseases, Humans, Immunity, Maternally-Acquired, Infant, Infant, Newborn, Long QT Syndrome, Lupus Erythematosus, Systemic, Male, Multicenter Studies as Topic, Myocardium, Pregnancy, Pregnancy Complications, Prospective Studies