Is CaMKII friend or foe for cell apoptosis in eye?: A narrative review.

Weixing Xu, Hua Liu

Journal: Medicine 2023;102(48):e36136

PMID: 38050317

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Abstract

Ca2+/calmodulin-dependent protein kinase II (CaMKII) controls cell proliferation, differentiation, apoptosis, and other biological processes that have an essential role in eye diseases. However, it seems that previous studies have generated conflicting conclusions about the effect of CaMKII on cell apoptosis. In this review, we explore the positive and potentially deleterious effects of CaMKII on eye cell apoptosis. We can safely conclude that the early elevation of CaMKII could be viewed as a promoter of cell apoptosis. Overexpression of CaMKII by transfection or pretreatment with drugs helped combat cell apoptosis.

Address: School of Graduate, Dalian Medical University, Dalian, China.; The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.; School of Graduate, Jinzhou Medical University, Jinzhou, China.

DOI: 10.1097/MD.0000000000036136

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MeSH Terms: Humans, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Apoptosis, Phosphorylation, Calcium