Efficacy of oral telithromycin in community-acquired pneumonia caused by resistant Streptococcus pneumoniae.

Dirkie van Rensburg, Charles Fogarty, María Cristina De Salvo, Manickam Rangaraju, Roomi Nusrat

Journal: The Journal of infection 2006;51(3):201-5

PMID: 16230216

Full Text on Elsevier Science View on PubMed

Abstract

The efficacy of oral telithromycin 800mg once daily for 7 days was evaluated in a multicentre, multinational study in patients with community-acquired pneumonia caused by Streptococcus pneumoniae resistant to penicillin and/or erythromycin. Per-protocol clinical and bacteriological outcomes were assessed 10-17 days post-therapy. Of the 129 patients with S. pneumoniae infection, 16 were infected with strains resistant to penicillin and/or erythromycin. Fifteen of these 16 patients (93.8%) were assessed as clinically and bacteriologically cured at the post-therapy visit.

Address: Drs Joynt, Venter and Associates, Medpark Center, P.O. Box 154, Witbank, 1035 South Africa. [email protected]

DOI: 10.1016/j.jinf.2004.11.004

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MeSH Terms: Administration, Oral, Adult, Aged, Anti-Bacterial Agents, Community-Acquired Infections, Drug Resistance, Bacterial, Erythromycin, Female, Humans, Ketolides, Male, Microbial Sensitivity Tests, Middle Aged, Penicillin Resistance, Penicillins, Pneumonia, Pneumococcal, Treatment Outcome