V I Shcherbakov, I M Pozdnyakov
Journal: Bulletin of experimental biology and medicine 2005;138(6):565-7
PMID: 16134815
The immunoregulatory effect of low-caloric diets on various components of the immune system was demonstrated. Serum content of TNF-alpha increased after the diet. Seasonal fluctuations in this parameter were observed in patients receiving these diets. A relationship between the increase in TNF-alpha level and body weight loss during low-caloric diet was detected. Presumably, transition to endogenous nutrition triggers not only catabolic hormones, but also cytokines with catabolic effects.
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