The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging.

Péter Torzsa, Mariann Moizs, Piroska Östlin, Yongjie Yon, Péter Varga, Zoltán Vokó, Magor Papp, István Takács, Barna Vásárhelyi, Andrea B Maier, Péter Ferdinandy, Anna Csiszar, Zoltán Benyó, Attila J Szabó, Gabriella Dörnyei, Mika Kivimäki, Miklos Kellermayer, Bela Merkely, Peter Mukli, Adam G Tabák, Roza Adany, György Purebl, Csilla Kaposvári, Vince Fazekas-Pongor, Tamás Csípő, Zsófia Szarvas, Krisztián Horváth, Zoltan Ungvari, Piroska Balog, Robert Bodizs, Peter Ujma, Adrienne Stauder, Daniel W Belsky, Illés Kovács, Andriy Yabluchanskiy

Journal: GeroScience 2024;46(1):191-218

PMID: 38060158

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Abstract

The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5% of whom are women. The study builds on the successful experiences of the Whitehall II study and aims to investigate the complex relationships between lifestyle, environmental, and occupational risk factors, and the development and progression of chronic age-associated diseases. An important goal of the Semmelweis Study is to identify groups of people who are aging unsuccessfully and therefore have an increased risk of developing age-associated diseases. To achieve this, the study takes a multidisciplinary approach, collecting economic, social, psychological, cognitive, health, and biological data. The Semmelweis Study comprises a baseline data collection with open healthcare data linkage, followed by repeated data collection waves every 5 years. Data are collected through computer-assisted self-completed questionnaires, followed by a physical health examination, physiological measurements, and the assessment of biomarkers. This article provides a comprehensive overview of the Semmelweis Study, including its origin, context, objectives, design, relevance, and expected contributions.

Address: International Training Program in Geroscience/Healthy Aging Program, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary. [email protected].; Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. [email protected].; Department of Health Promotion Sciences, The Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. [email protected].; International Training Program in Geroscience/Healthy Aging Program, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary.; Department of Public Health, Faculty of Medicine, Semmelweis University, Budapest, Hungary.; UCL Brain Sciences, University College London, London, UK.; Department of Internal Medicine and Oncology, Semmelweis University, Faculty of Medicine, Budapest, Hungary.; HUN-REN-UD Public Health Research Group, Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.; Institute of Behavioral Sciences, Faculty of Medicine, Semmelweis University, Budapest, Hungary.; Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; Department of Health Promotion Sciences, The Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; Robert N. Butler Columbia Aging Center, Columbia University, New York, NY, USA.; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.; Department of Ophthalmology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.; Department of Ophthalmology, Weill Cornell Medical College, New York City, NY, USA.; Department of Clinical Ophthalmology, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary.; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Centre for Healthy Longevity, National University Health System, Singapore, Singapore.; Department of Human Movement Sciences, @AgeAmsterdam, Vrije Universiteit, Amsterdam Movement Sciences, Amsterdam, The Netherlands.; Ministry of Interior of Hungary, Budapest, Hungary.; WHO Regional Office for Europe, Copenhagen, Denmark.; Clinical Center, Semmelweis University, Budapest, Hungary.; Center for Health Technology Assessment, Semmelweis University, Budapest, Hungary.; Department of Laboratory Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary.; Department of Family Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary.; Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary.; Department of Translational Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary.; HUN-REN-SU Cerebrovascular and Neurocognitive Diseases Research Group, Budapest, Hungary.; First Department of Pediatrics, Faculty of Medicine, Semmelweis University, Budapest, Hungary.; HUN-REN-SU Pediatrics and Nephrology Research Group, Semmelweis University, Budapest, Hungary.; Department of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary.; Department of Biophysics and Radiation Biology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.; Heart and Vascular Center, Semmelweis University, Budapest, Hungary.

DOI: 10.1007/s11357-023-01018-7

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MeSH Terms: Humans, Female, Male, Healthy Aging, Universities, Cohort Studies, Prospective Studies, Hungary