Optimization of an accelerator-based epithermal neutron source for neutron capture therapy.

O E Kononov, V N Kononov, M V Bokhovko, V V Korobeynikov, A N Soloviev, A S Sysoev, I A Gulidov, W T Chu, D W Nigg

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2005;61(5):1009-13

PMID: 15308184

Full Text on Elsevier Science View on PubMed

Abstract

A modeling investigation was performed to choose moderator material and size for creating optimal epithermal neutron beams for BNCT based on a proton accelerator and the (7)Li(p,n)(7)Be reaction as a neutrons source. An optimal configuration is suggested for the beam shaping assembly made from polytetrafluoroethylene and magnesium fluorine to be placed on high current IPPE proton accelerator KG-2.5. Results of calculation were experimentally tested and are in good agreement with measurements.

Address: State Scientific Center of Russian Federation, Institute for Physics and Power Engineering, Bondarenko sq. 1, 249033 Obninsk, Kaluga, Russia. [email protected]

DOI: 10.1016/j.apradiso.2004.05.028

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MeSH Terms: Boron Neutron Capture Therapy, Computer Simulation, Facility Design and Construction, Fast Neutrons, Humans, Monte Carlo Method, Neoplasms, Particle Accelerators, Phantoms, Imaging, Radiotherapy Dosage