Molecular genetic basis of sudden cardiac death.

Jeffrey A Towbin

Journal: Pediatric clinics of North America 2004;51(5):1229-55

PMID: 15331282

Full Text on Elsevier Science View on PubMed

Abstract

This article outlines the up-to-date understanding of the molecular basis of disorders that cause sudden death. Several arrhythmic disorders that cause sudden death have been well-described at the molecular level, including the long QT syndromes and Brugada syndrome; this article reviews the current scientific knowledge of these diseases. Hypertrophic cardiomyopathy, a myocardial disorder that causes sudden death also has been well-studied. Finally, a disorder in which myocardial abnormalities and rhythm abnormalities coexist, arrhythmogenic right ventricular dysplasia, is described.

Address: Department of Pediatrics (Cardiology), Texas Children's Hospital and Baylor College of Medicine, 6621 Fannin Street, FC. 430.09, Houston, TX 77030, USA. [email protected]

DOI: 10.1016/j.pcl.2004.04.012

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MeSH Terms: Arrhythmias, Cardiac, Arrhythmogenic Right Ventricular Dysplasia, Cardiomyopathy, Hypertrophic, Familial, Child, Death, Sudden, Cardiac, ERG1 Potassium Channel, Ether-A-Go-Go Potassium Channels, Humans, KCNQ Potassium Channels, KCNQ1 Potassium Channel, Long QT Syndrome, NAV1.5 Voltage-Gated Sodium Channel, Potassium Channels, Potassium Channels, Voltage-Gated, Sodium Channels, Syndrome, Tachycardia, Ventricular, Wolff-Parkinson-White Syndrome