Diverse catalytic activities in the alphabeta-hydrolase family of enzymes: activation of H2O, HCN, H2O2, and O2.

Timothy D H Bugg

Journal: Bioorganic chemistry 2005;32(5):367-75

PMID: 15381402

Full Text on Elsevier Science View on PubMed

Abstract

The article describes the observation of novel catalytic activities in the alphabeta-hydrolase superfamily apparently unrelated to ester hydrolysis and unexpected biochemical observations relating to the structure and function of the serine catalytic triad in these enzymes. One common feature of these novel activities is the activation of a small diatomic molecule, but via diverse chemistry. Possible mechanisms of catalysis are discussed.

Address: Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK. [email protected]

DOI: 10.1016/j.bioorg.2004.05.005

Link outs

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0045...

MeSH Terms: Catalysis, Hydrogen Cyanide, Hydrogen Peroxide, Hydrolases, Isoenzymes, Oxygen, Protein Conformation, Protein Structure, Secondary, Water