Geroprotector drugs and exercise: friends or foes on healthy longevity?

Christian J Elliehausen, Rozalyn M Anderson, Gary M Diffee, Timothy W Rhoads, Dudley W Lamming, Troy A Hornberger, Adam R Konopka

Journal: BMC biology 2023;21(1):287

PMID: 38066609

Free Full Text on BioMed Central View on PubMed

Abstract

Physical activity and several pharmacological approaches individually combat age-associated conditions and extend healthy longevity in model systems. It is tantalizing to extrapolate that combining geroprotector drugs with exercise could extend healthy longevity beyond any individual treatment. However, the current dogma suggests that taking leading geroprotector drugs on the same day as exercise may limit several health benefits. Here, we review leading candidate geroprotector drugs and their interactions with exercise and highlight salient gaps in knowledge that need to be addressed to identify if geroprotector drugs can have a harmonious relationship with exercise.

Address: Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; Geriatric Research, Education, and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.; Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, USA.; Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.; Division of Endocrinology, Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, USA.; Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA. [email protected].; Geriatric Research, Education, and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA. [email protected].

DOI: 10.1186/s12915-023-01779-9

Link outs

Free resources

Full Text Sources:

MeSH Terms: Humans, Longevity, Senotherapeutics, Exercise, Aging