Regulation of MMP-9 gene expression for the development of novel molecular targets against cancer and inflammatory diseases.

Yves St-Pierre, Julie Couillard, Céline Van Themsche

Journal: Expert opinion on therapeutic targets 2005;8(5):473-89

PMID: 15469396

Abstract

The need to pharmacologically control the proteolytic activity of matrix metalloproteinases (MMPs) has been commonly acknowledged, despite its limited efficacy in clinical trials. Among the reasons that explain this failure is our limited understanding of the signals that control the expression of MMPs in different cell types during different pathological conditions. Thus, future therapies must rely on more selective approaches. With the continually increasing body of proof implicating MMPs in a large number of diseases, it has become a priority to establish the pertinence of molecules involved in the signalling pathways leading to the expression of these enzymes. MMP-9 is a case in point: its dramatic overexpression in cancer and various inflammatory conditions clearly points to the molecular mechanisms controlling its expression as a potential target for eventual rational therapeutic intervention. In this article, recent progress in the signalling pathways that regulate MMP-9 expression is reviewed, and the latest strategies to be considered in the search for a specific inhibitor of its expression are presented.

Address: INRS-Institut Armand-Frappier, University of Quebec, 531 Boulevard des Prairies, Laval, Quebec, H7V 1B7, Canada. [email protected]

DOI: 10.1517/14728222.8.5.473

Link outs

Free resources

Miscellaneous:

https://assays.cancer.gov/non-CPTAC-4047

Subscription / membership required

Full Text Sources:

https://www.tandfonline.com/doi/10.1517/14728222.8...

MeSH Terms: Anti-Inflammatory Agents, Antineoplastic Agents, Binding Sites, Consensus Sequence, Dinoprostone, Drug Design, Enzyme Induction, Enzyme Inhibitors, Epigenesis, Genetic, Gene Expression Regulation, Enzymologic, Genes, Transgenic, Suicide, Genetic Therapy, Humans, Inflammation, Isoenzymes, Matrix Metalloproteinase 9, Matrix Metalloproteinase Inhibitors, Mitogen-Activated Protein Kinases, Models, Biological, NF-kappa B, Neoplasms, Oligonucleotides, Antisense, Phytotherapy, Promoter Regions, Genetic, Protein Kinase C, Signal Transduction, Transcription Factors