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Physiological and Molecular Function of the Sodium/Hydrogen Exchanger NHA2 (SLC9B2).

Tin Manh Ho, Stephan Berger, Philipp Müller, Céline Simonin, Jean-Louis Reymond, Christoph Von Ballmoos, Daniel G Fuster

Journal: Chimia 2023;76(12):1019-1024

PMID: 38069797

Free Full Text on Swiss Chemical Society View on PubMed

Abstract

NHA2, also known as SLC9B2, is an orphan intracellular Na+/H+ exchanger (NHE) that has been associated with arterial hypertension and diabetes mellitus in humans. The objective of this NCCR TransCure project was to define the physiological and molecular function of NHA2, to develop a high resolution kinetic transport assay for NHA2 and to identify specific and potent compounds targeting NHA2. In this review, we summarize the results of this highly interdisciplinary and interfaculty effort, led by the groups of Proffs. Jean-Louis Reymond, Christoph von Ballmoos and Daniel Fuster.

Copyright 2022 Tin Manh Ho, Stephan Berger, Philipp Müller, Céline Simonin, Jean-Louis Reymond, Christoph von Ballmoos, Daniel G. Fuster. License: This work is licensed under a Creative Commons Attribution 4.0 International License.

Address: Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern. [email protected].; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Switzerland. [email protected].; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Switzerland. [email protected].; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Switzerland.; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Switzerland. [email protected].; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Switzerland. [email protected].; Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern. [email protected].
DOI: 10.2533/chimia.2022.1019

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MeSH Terms: Humans, Antiporters, Sodium-Hydrogen Exchangers
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