Amiodarone-induced thyrotoxicosis and thyroid cancer: clinical, immunohistochemical, and molecular genetic studies of a case and review of the literature.

David L Steward, Aly Saad, Mercedes Falciglia, Yuri E Nikiforov

Journal: Archives of pathology & laboratory medicine 2004;128(7):807-10

PMID: 15214815

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Abstract

Amiodarone-induced thyrotoxicosis (AIT) is a well-known complication of amiodarone treatment found in 3% to 12% of patients. Two types of AIT have been described, each associated with a distinct histologic pattern of thyroid involvement. Type 1, which typically develops in the background of pre-existing thyroid disease, is due to iodine-induced excess thyroid hormone synthesis, whereas type 2 is due to destructive thyroiditis. The prevalence of thyroid cancer in patients with AIT is unknown. We report a case of papillary thyroid carcinoma associated with type 2 AIT.

Address: Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267-0529, USA.

DOI: 10.5858/2004-128-807-ATATCC

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MeSH Terms: Amiodarone, Anti-Arrhythmia Agents, Carcinoma, Papillary, Follicular, Humans, Immunohistochemistry, Male, Middle Aged, Mutation, Thyroid Neoplasms, Thyrotoxicosis