Where did the BLOSUM62 alignment score matrix come from?

Sean R Eddy

Journal: Nature biotechnology 2005;22(8):1035-6

PMID: 15286655

Full Text on Nature Publishing Group View on PubMed

Abstract

Many sequence alignment programs use the BLOSUM62 score matrix to score pairs of aligned residues. Where did BLOSUM62 come from?

Address: Howard Hughes Medical Institute & Department of Genetics, Washington University School of Medicine, 4444 Forest Park Blvd., Box 8510, Saint Louis, Missouri 63108, USA. [email protected]

DOI: 10.1038/nbt0804-1035

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https://doi.org/10.1038/nbt0804-1035

MeSH Terms: Algorithms, Proteins, Sequence Alignment, Sequence Analysis, Protein, Sequence Homology, Amino Acid