Add-on gabapentin in the treatment of opiate withdrawal.

José Martínez-Raga, Ana Sabater, Bartolome Perez-Galvez, Miguel Castellano, Gaspar Cervera

Journal: Progress in neuro-psychopharmacology & biological psychiatry 2004;28(3):599-601

PMID: 15093968

Full Text on Elsevier Science View on PubMed

Abstract

Gabapentin is an antiepileptic drug shown to be effective in the treatment of pain disorders and appears to be useful as well for several psychiatric disorders, including bipolar disorder, anxiety disorders, alcohol withdrawal and cocaine dependence. Gabapentin, at a dose of 600 mg three times a day, was evaluated as an add-on medication to a standard detoxification regime in seven heroin dependent individuals undergoing outpatient opiate withdrawal treatment. All seven patients successfully completed opiate detoxification and commenced opiate antagonist treatment with naltrexone on day five of withdrawal treatment, as scheduled. No adverse event was noted. Gabapentin appeared to lead a reduction in symptomatic medication and an overall beneficial effect on symptoms of heroin withdrawal.

Address: Unidad de Conductas Adictivas del Area 9 de Salud Valencia, Consellería de Sanitat, and Universidad Cardenal Herrera-CEU, Generalitat Valenciana, Spain. [email protected]

DOI: 10.1016/j.pnpbp.2003.11.020

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MeSH Terms: Acetates, Adult, Amines, Cyclohexanecarboxylic Acids, Excitatory Amino Acid Antagonists, Female, Gabapentin, Heroin, Heroin Dependence, Humans, Male, Naltrexone, Narcotic Antagonists, Narcotics, Recurrence, Substance Withdrawal Syndrome, gamma-Aminobutyric Acid