Molecular genetics of human prostate cancer.

Angelo M De Marzo, Mark A Rubin

Journal: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2004;17(3):380-8

PMID: 14752525

Free Full Text on Elsevier Science View on PubMed

Abstract

Multiple factors contribute to the high incidence and prevalence of prostate cancer including race, ethnicity, diet, environment, widespread awareness through prostate-specific antigen screening and genetics. Linkage analysis has identified several candidate sites for hereditary prostate cancer gene loci. Molecular studies have also identified genes that are frequently altered in sporadic prostate cancer. It appears that due to the heterogeneity of prostate cancer, multiple genes may be involved in the neoplastic process.

Address: Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA. [email protected]

DOI: 10.1038/modpathol.3800051

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MeSH Terms: Chromosomal Instability, Computational Biology, Disease Progression, Dissection, Humans, Laser Therapy, Male, Molecular Biology, Prostatic Neoplasms, Proteomics, Receptors, Androgen, Telomere