Hepatitis C virus-positive donors in HCV-negative recipients in liver transplantation: Is it possible in Mexico?

J A Torres-Díaz, E A Jasso-Baltazar, L Toapanta-Yanchapaxi, J Aguirre-Valadez, L Martínez-Matínez, A Sánchez-Cedillo, D Aguirre-Villarreal, I García-Juárez

Journal: Revista de gastroenterologia de Mexico (English) 2024;88(4):392-403

PMID: 38097433

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Abstract

Hepatitis C virus (HCV) infection is a worldwide public health problem associated with significant morbidity and mortality. In the context of liver transplantation, the demand for organs continues to exceed the supply, prompting the consideration of using organs from HCV-positive donors in HCV-negative recipients. The introduction of direct-acting antivirals (DAAs), which have demonstrated great efficacy in eradicating the virus, has made transplantation of organs from donors with HCV infection possible. The present article provides a brief review of the current evidence on the use of organs from HCV-infected patients.

Address: Unidad de Hepatología y Trasplante, Departamento de Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.; Unidad de Hepatología y Trasplante, Departamento de Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; Departamento de Gastroenterología, Hospital Ángeles Pedregal, Mexico City, Mexico.; Departamento de Gastroenterología, Hospital Ángeles Pedregal, Mexico City, Mexico.; Departamento de trasplante, Hospital General de México, Mexico City, Mexico.; Unidad de Hepatología y Trasplante, Departamento de Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. Electronic address: [email protected].

DOI: 10.1016/j.rgmxen.2023.08.002

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Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S2255...

Medical:

https://medlineplus.gov/hepatitisc.html

MeSH Terms: Humans, Hepacivirus, Liver Transplantation, Antiviral Agents, Mexico, Hepatitis C, Chronic, Hepatitis C