Efficacy of topical treatment with aescin + essential phospholipids gel in venous insufficiency and hypertension.

I Ruffini, G Belcaro, M R Cesarone, M Dugall

Journal: Angiology 2004;55 Suppl 1():S19-21

PMID: 15156253

Abstract

Aescin and essential phospholipids (AEPL) in a gel was used in a microcirculatory model to assess the effects on skin perfusion in chronic venous insufficiency and severe venous hypertension. The aim of this efficacy study was to evaluate the efficacy of an AEPL gel on the microcirculation measuring transcutaneous skin PO(2) and PCO(2) in subjects with chronic venous insufficiency, venous hypertension (CVH), and venous microangiopathy. Transcutaneous PO(2) and PCO(2) were measured at the internal perimalleolar region. After 2 weeks of treatment with AEPL, all TcPO(2) individual values were increased and all PCO(2) values were decreased (p < 0.05). Average values were significantly changed toward normal. Therefore, considering skin PO(2) and PCO(2) variations, local treatment with AEPL in areas of venous microangiopathy is very effective in improving skin perfusion and nutrition and, possibly, in preventing venous ulcerations.

Address: Irvine2 Vascular Laboratory, Department of Biomedical Sciences, G. D'Annunzio University, Italy.

DOI: 10.1177/000331970405500605

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MeSH Terms: Administration, Topical, Adult, Carbon Dioxide, Chronic Disease, Drug Combinations, Escin, Female, Gels, Humans, Male, Microcirculation, Middle Aged, Oxygen, Phosphatidylcholines, Skin, Venous Insufficiency, Venous Pressure