Inner ear: Ca(2+)n you feel the noise?

Brian M McDermott, Hernán López-Schier

Journal: Current biology : CB 2004;14(6):R231-2

PMID: 15043832

Free Full Text on Elsevier Science View on PubMed

Abstract

The death of hair cells in the inner ear as a result of exposure to loud noise can lead to irreversible deafness. New work shows that the mammalian cochlea can sense noxious sounds and use Ca(2+) waves to rapidly propagate hair cell damage signals.

Address: Laboratory of Sensory Neuroscience, The Rockefeller University (314), 1230 York Avenue, New York, New York 10021, USA. [email protected]

DOI: 10.1016/j.cub.2004.02.053

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https://assays.cancer.gov/CPTAC-177

MeSH Terms: Adenosine Triphosphate, Calcium Signaling, Hair Cells, Auditory, Humans, Inositol 1,4,5-Trisphosphate, Organ of Corti, Receptors, Purinergic P2, Signal Transduction, Sound