The biochemical basis of the health effects of exercise: an integrative view.

R Andrew Shanely, Frank W Booth

Journal: The Proceedings of the Nutrition Society 2005;63(2):199-203

PMID: 15294030

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Abstract

Physical inactivity-gene interactions result in changes in gene expression, leading to phenotypic changes in the skeletal muscle cell. A subpopulation of those genes that show changes in expression during physical inactivity are candidates for the environment-gene interactions that cross a threshold of biological significance such that overt clinical disease occurs. AMP kinase, GLUT4 and myosin heavy chain IIx are proposed as candidates for physical inactivity-modulated genes that have an altered function that may trigger a crossing of a threshold to disease. Future experiments will be needed to test the validity of the ideas presented.

Address: Department of Biomedical Sciences, Department of Medical Pharmacology and Physiology, Dalton Cardiovascular Institute, University of Missouri, Columbia, Missouri 65211, USA. [email protected]

DOI: 10.1079/pns2004337

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MeSH Terms: Adenylate Kinase, Environment, Exercise, Gene Expression, Glucose Transporter Type 4, Humans, Life Style, Monosaccharide Transport Proteins, Muscle Proteins, Muscle, Skeletal, Myosin Heavy Chains