Construction of Mn doped CuS nanozymes for synergistic tumor therapy in NIR-I/II bio-windows.

Meng Wang, Qi Huang, Ruixin Ma, Shuozhe Wang, Xinxiu Li, Youhui Hu, Shunhua Zhu, Min Zhang, Qingli Huang

Journal: Colloids and surfaces. B, Biointerfaces 2024;234():113689

PMID: 38103429

Full Text on Elsevier Science View on PubMed

Abstract

In photothermal therapy (PTT) and chemodynamic therapy (CDT) of cancer, poor performance of nanoagents severely impaired the therapeutic effect of cancer. To solve the problem, we proposed and constructed a novel Mn doped CuS phothermal nanoagent both in the first near-infrared (NIR-I) and the second near- infrared (NIR-II) windows in this work, which exhibited high photothermal conversion efficiency of 40.3% at 808 nm (NIR-I window) and 33.4% at 1064 nm (NIR-II window), as well as outstanding pH-sensitive catalytic performance (peroxidase-like catalytic activity and Fenton-like catalytic activities). The as-prepared Mn doped CuS could be used to load chemotherapy drug doxorubicin (DOX) after modified by folic acid. Both in vitro and in vivo studies indicated that it could be used as nanoagent for chemodynamic therapy (CDT)/photothermal therapy (PTT)/ chemotherapy of cervical carcinoma. This study thus provided an NIR-I/NIR-II/pH responsive nanoagent for potential synergistic therapy of deep-seated tumors.

Address: Public Experimental Research Center, the Second Clinical Medical College, Medical Technology School of Xuzhou Medical University, Xuzhou city, Jiangsu 221004, China.; Public Experimental Research Center, the Second Clinical Medical College, Medical Technology School of Xuzhou Medical University, Xuzhou city, Jiangsu 221004, China; School of Life Sciences, Nursing, Medical Imaging and Pharmacy of Xuzhou Medical University, Xuzhou city, Jiangsu 221000, China.; School of Life Sciences, Nursing, Medical Imaging and Pharmacy of Xuzhou Medical University, Xuzhou city, Jiangsu 221000, China.; Public Experimental Research Center, the Second Clinical Medical College, Medical Technology School of Xuzhou Medical University, Xuzhou city, Jiangsu 221004, China. Electronic address: [email protected].

DOI: 10.1016/j.colsurfb.2023.113689

Link outs

Free resources

Medical:

https://medlineplus.gov/cancer.html

Miscellaneous:

https://assays.cancer.gov/CPTAC-1744

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0927...

MeSH Terms: Humans, Phototherapy, Doxorubicin, Neoplasms, Cell Line, Tumor, Nanoparticles